Welcome to COVID Questions, TIME’s recommendation column. We’re attempting to make residing by way of the pandemic a bit simpler, with expert-backed solutions to your hardest coronavirus-related dilemmas. Whereas we will’t and don’t provide medical recommendation—these questions ought to go to your physician—we hope this column will assist you type by way of this worrying and complicated time. Bought a query? Write to us at [email protected]time.com.

As we speak, N.C. in Washington, D.C., asks:

I received a Johnson & Johnson vaccine. With the Delta variant spreading, I’ve heard that some individuals in my place are additionally getting pictures of Pfizer or Moderna for further safety. Is that one thing I ought to do, too? And if booster pictures grow to be beneficial afterward, ought to I swap to Pfizer or Moderna?

It’s true that vaccines made with mRNA—these from Pfizer-BioNTech and Moderna—provide stronger safety towards preliminary COVID-19 strains than Janssen/Johnson & Johnson’s adenovirus-based shot. That’s why some individuals who received Johnson & Johnson’s vaccine are taken with doubling up, notably because the extra transmissible Delta variant continues to unfold within the U.S.

The U.S. Facilities for Illness Management and Prevention’s (CDC) official stance is that COVID-19 pictures aren’t interchangeable. That doesn’t essentially imply it’s unprotected to combine them; there’re simply not loads of information obtainable to reply the query.

Some distinguished researchers have determined to forge forward and get mRNA boosters on prime of Johnson & Johnson pictures, even with out an official blessing from the CDC—and even supposing some pharmacies gained’t give further pictures to people who find themselves already absolutely vaccinated.

Dr. Hana Mohammed El Sahly, a molecular virology and microbiology knowledgeable at Baylor Faculty of Medication, isn’t a kind of researchers—and he or she says she wouldn’t advocate that plan of action. “Till we’ve higher information, it most likely isn’t clever to go and get [additional] vaccines except it’s a part of a medical trial,” she says.

These information are on the way in which. Nationwide Institutes of Well being (NIH) scientists are learning what occurs when individuals get a booster of a unique vaccine than their authentic shot. That research contains the Johnson & Johnson vaccine.

European analysis groups have additionally printed outcomes suggesting that it’s efficient to combine one dose of Pfizer-BioNTech’s vaccine with one dose of the shot made by AstraZeneca-Oxford College—which, like Johnson & Johnson’s vaccine, is adenovirus-based. That’s not a direct parallel, nevertheless it does assist the final idea of blending and matching doses. Nations together with Germany, Canada and the Dominican Republic are already attempting out such programs, however none of them are mixing Johnson & Johnson pictures with different vaccines.

Security apart, a second shot won’t even be crucial. A brand new research printed in Nature discovered that individuals who had been solely partially vaccinated (i.e., who obtained just one shot out of a two-dose routine) had been vulnerable to the Delta variant, however that absolutely vaccinated people had been a lot better protected. The research didn’t analyze Johnson & Johnson’s shot, however individuals who get the one-dose vaccine are thought of absolutely vaccinated by the CDC.

Johnson & Johnson says its vaccine—like others licensed within the U.S.—works properly towards the Delta variant, though that conclusion got here from a really small research. Even with the Delta variant spreading, El Sahly notes, the overwhelming majority of people that find yourself hospitalized or die from COVID-19 are unvaccinated, which suggests the pictures proceed to work properly as licensed.

When you’re involved, El Sahly says your finest guess, no less than for now, is returning to precautions like masking and social distancing—not getting a second kind of vaccine.

That recommendation could change down the street. Consultants have mentioned it’s potential that everybody will want a booster shot roughly a 12 months after vaccination, relying on how lengthy they supply safety towards the virus. By the point well being officers know whether or not boosters are crucial, El Sahly says, researchers will hopefully have gathered sufficient information to make a advice about whether or not it’s best to keep on with Johnson & Johnson or swap to Pfizer-BioNTech or Moderna.

And for those who’re completely determined to get double-vaccinated within the meantime, the NIH’s research on mix-and-match dosing is enrolling now. “You may volunteer there and assist us generate these information,” El Sahly says.

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